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THELBAN 100MG/5ML SYRUP 20ML (ALBENDAZOLE)


    RM 12.00

BOTTLE

Contents
Albendazole.

Description
Thelban Tablet: Each tablet contains: Albendazole 200 mg.
Thelban Suspension: Each 5 mL contains: Albendazole 100 mg, Methylparaben (as preservative) 0.15%, Propylparaben (as preservative) 0.02%.

Action
Pharmacology: Pharmacodynamics: THELBAN (Albendazole) is an anthelmintic exhibits vermicidal, ovicidal and larvacidal activity.
Pharmacokinetics: Albendazole is poorly absorbed from gastro-intestinal tract after oral administration, but rapidly undergoes extensive first-pass metabolism. The principal metabolite (albendazole sulfoxide) has anthelmintic activity, and a plasma half-life of about 8 ½ hours, it is excreted in the urine together with other metabolites including albendazole sulfone and the 2-amino-sulfoxide and 2-amino sulfone.

Indications/Uses
Anthelmintic which exhibits vermicidal, ovicidal and larvacidal activity in the treatment of Roundworm (Ascaris lumbricoides), Whipworm (Trichuris trichiura), Pinworm or Threadworm (Enterobius vermicularis), Hookworm (Ancylostoma duodenale and Necator americanus), Strongyloides stercoralis, Taenia solium, Taenia saginata and Opisthorchis viverrini.

Dosage/Direction for Use
Adults and children over 2 years of age: The usual dosage is 400 mg as a single dose with meal.
In cases of Strongyloides infestation: The usual dosage is 400 mg once daily for three consecutive days.
In cases of Opisthorchis viverrini: The usual dosage is 400 mg twice daily for three consecutive days.

Route of Administration: Oral.

Overdosage
No symptoms of overdosage have been reported. Should they occur, symptomatic treatment should be provided.

Contraindications
Albendazole should not be administered during pregnancy or in women thought to be pregnant.

Special Precautions
Patients receiving high doses of albendazole such as those with hydatid disease, should be supervised closely.

Use In Pregnancy & Lactation
Pregnancy: Albendazole should not be administered during pregnancy or in women thought to be pregnant.
Lactation: It is not known whether it is excreted in human milk, caution should be exercised when albendazole is administered.

Adverse Reactions
Since albendazole is poorly absorbed from the gastro-intestinal tract at the usual therapeutic doses, side effects have generally been restricted to gastro-intestinal disturbances such as transient abdominal pain and diarrhoea.
However, adverse effects have been reported more frequently with high doses tried in the treatment of hydatid disease and have included allergic reactions, raised liver enzymes values, leucopenia and alopecia.

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